How is rosuvastatin metabolized?

How is rosuvastatin metabolized?

Rosuvastatin is metabolized mainly by CYP2C9 and not extensively metabolized; approximately 10% is recovered as metabolite N-desmethyl rosuvastatin. It is excreted in feces (90%) primarily and the elimination half-life is approximately 19 hours.

How is Crestor synthesized?

Synthesis of rosuvastatin starts from Knoevenagel condensation of ethyl isobutyrylacetate (20.1. 33) with p-fluorobenzaldehyde (20.1. 9), which provided the benzylidene keto ester (20.1. 34), cyclocondensation of which with S-methylisothiourea in hexamethylphosphoramide (HMPA) at 100oC produced the intermediate (20.1.

What is rosuvastatin half-life?

Excretion: Following oral administration, rosuvastatin and its metabolites are primarily excreted in the feces (90%). The elimination half-life (t1/2) of rosuvastatin is approximately 19 hours. After an intravenous dose, approximately 28% of total body clearance was via the renal route, and 72% by the hepatic route.

How does rosuvastatin work in the body?

Rosuvastatin is in a class of medications called HMG-CoA reductase inhibitors (statins). It works by slowing the production of cholesterol in the body to decrease the amount of cholesterol that may build up on the walls of the arteries and block blood flow to the heart, brain, and other parts of the body.

What can you not take with rosuvastatin?

Do not take any red yeast rice products while you are taking rosuvastatin because some red yeast rice products may also contain a statin called lovastatin. Taking rosuvastatin and red yeast rice products together can increase your risk of serious muscle and liver problems.

Is rosuvastatin banned?

As you are aware, on March 4th of this year, we petitioned the FDA to ban the recently-marketed cholesterol-lowering drug rosuvastatin (Crestor/AstraZeneca) because of seven post-marketing cases of life-threatening rhabdomyolysis and nine cases of renal failure or renal insufficiency, both of which problems had also …

What foods should be avoided when taking Crestor?

Common Foods to Avoid When Taking Crestor

  • Baked goods.
  • Butter.
  • Fatty or processed meats.
  • Fast food.
  • Fried food.
  • Full-fat dairy foods.
  • Tropical oils.

Can I take vitamin D with rosuvastatin?

Interactions between your drugs No interactions were found between rosuvastatin and Vitamin D3. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

Does rosuvastatin cause sleep problems?

The top-selling statins are atorvastatin (Lipitor), lovastatin (Mevacor), rosuvastatin (Crestor) and simvastatin (Zocor). How they can cause insomnia: The most common side effect of all types of statins is muscle pain, which can keep people who take them awake at night and unable to rest.

What is the best time to take rosuvastatin?

Studies show that some of the newer statins can be just as effective when taken in the morning. HMG-CoA reductase inhibitors such as atorvastatin and rosuvastatin are more potent than older statins. They have half-lives of at least 14 hours. Extended-release fluvastatin, or Lescol XL, can be taken at any time of day.