What are oxazolidinone antibiotics used for?

Oxazolidinones are primarily used for the treatment of antimicrobial-resistant gram-positive bacterial infections caused by methicillin-resistant staphylococci, vancomycin-resistant enterococci and penicillin-resistant pneumococci. Linezolid is also used to treat multidrug-resistant Mycobacterium tuberculosis.

Who discovered oxazolidinone?

Pharmacia Corporation scientists initiated a discovery research program in oxazolidinone chemistry and biology. Indanone-, tetralone-, and indoline-subunit oxazolidinones provided proof-of-concept interim improvements in antibacterial activity and safety SAR for the program.

Which drug belongs to the class of oxazolidinone?

Oxazolidinones

What is the mechanism of action of linezolid?

Linezolid is bacteriostatic with a unique mechanism of action. It inhibits protein synthesis by binding to a site on the bacterial 23S ribosomal RNA of the 50S subunit. This prevents formation of the 70S ribosomal unit; therefore protein synthesis is inhibited.

Is Sulphanilamide an antibiotic?

Sulfanilamide (also spelled sulphanilamide) is a sulfonamide antibacterial drug. Chemically, it is an organic compound consisting of an aniline derivatized with a sulfonamide group.

Which antibiotics are quinolones?

The fluoroquinolone antibiotics include ciprofloxacin (Cipro), gemifloxacin (Factive), levofloxacin (Levaquin), moxifloxacin (Avelox), and ofloxacin (Floxin).

Why is linezolid so expensive?

Much of the high cost of linezolid has been attributed to the expense of its synthesis.

What is Zylox?

Zyvox (linezolid) is an oxazolidinone antibiotic that fights bacteria in the body. Linezolid is also an MAO (monoamine oxidase) inhibitor. Zyvox is used to treat different types of bacterial infections, such as pneumonia, skin infections, and infections that are resistant to other antibiotics.

Is Oxazolidinedione a class?

The oxazolidinones, a new chemical class of synthetic antimicrobial agent, have a unique mechanism of inhibiting bacterial protein synthesis.

What drugs are Lincosamides?

Lincosamides are a class of antibiotics, which include lincomycin, clindamycin, and pirlimycin.

What kind of antibiotic is linezolid?

Linezolid is a synthetic antibiotic belonging to a new class of antimicrobials called the oxazolidinones. Linezolid disrupts bacterial growth by inhibiting the initiation process of protein synthesis—a mechanism of action that is unique to this class of drugs.

Why do we use linezolid?

Linezolid is an antibiotic that fights bacteria in the body. Linezolid is also an MAO (monoamine oxidase) inhibitor. Linezolid is used to treat different types of bacterial infections, such as pneumonia, skin infections, and infections that are resistant to other antibiotics.

What kind of bacteria is oxazolidinone used for?

Linezolid, the first oxazolidinone to be approved for clinical use, displays in-vitro activity (generally bacteriostatic) against many important resistant pathogens, including meticillin-resistant Staph aureus, vancomycin-resistant enterococci, and penicillin-resistant Strep pneumoniae.

What is the mechanism of action of oxazolidinone?

The oxazolidinones, a new chemical class of synthetic antimicrobial agent, have a unique mechanism of inhibiting bacterial protein synthesis.

Which is the first antibiotic in the market?

Linezolid (Zyvox) is the first member of an entirely new class of antibiotics to reach the market in over 35 years; it was approved for use in 2000.

How are oxazolidinone analogs related to tuberculosis?

Recent results have demonstrated that oxazolidinone analogs related to linezolid are effective in treating pulmonary tuberculosis caused by resistant Mycobacterium tuberculosis in animal infection models and suggest additional new therapeutic applications for these antibiotics. © 2011 New York Academy of Sciences. Research Support, Non-U.S. Gov’t