What is coagulation factor IX?
What is coagulation factor IX?
Factor IX is a protein produced naturally in the body. It helps the blood form clots to stop bleeding. Injections of factor IX are used to treat hemophilia B, which is sometimes called Christmas disease.
What is human factor IX?
Human Factor IX (Christmas factor) is a single-chain plasma glycoprotein (mol wt 57,000) that participates in the middle phase of the intrinsic pathway of blood coagulation.
How do you calculate factor IX?
How to Calculate Dosage for Hemophilia B (Factor IX)
- Take the patient’s present weight in pounds.
- Divide that weight by 2.2 (a calculator may help).
- Multiply that number by the factor level to be reached.
- The result is the required units of factor.
What is factor IX called?
Hemophilia B, also called factor IX (FIX) deficiency or Christmas disease, is a genetic disorder caused by missing or defective factor IX, a clotting protein. Although it is passed down from parents to children, about 1/3 of cases are caused by a spontaneous mutation, a change in a gene.
What does elevated Factor 9 mean?
High levels of coagulation factor IX may play a role in the risk of developing a blood clot. The Leiden Thrombophilia Study found that levels of FIX in the 90th percentile and higher increased the risk of blood clots by two- to three-fold.
What is factor 10 called?
COAGULATION CASCADE | Factor X Factor X (fX), also called Stuart factor, is a vitamin-K dependent serine protease zymogen that is activated in the first common step of the intrinsic and extrinsic pathways of blood coagulation.
What is Factor 8 called?
Factor VIII (FVIII) is an essential blood-clotting protein, also known as anti-hemophilic factor (AHF). In humans, factor VIII is encoded by the F8 gene. Defects in this gene result in hemophilia A, a recessive X-linked coagulation disorder.
What is the result of a deficiency of factor IX?
Hemophilia B is the result of a deficiency of clotting factor IX. The severity of symptoms can vary, and the severe forms become apparent early on. Bleeding is the main symptom of the disease and sometimes, though not always, occurs if an infant is circumcised.
What is factor VIII in hemophilia?
May also be called: Factor VIII Deficiency. Hemophilia is a disease that prevents blood from clotting properly. A clot helps stop bleeding after a cut or injury. In factor VIII deficiency (hemophilia A), the body doesn’t make enough factor VIII (factor 8), one of the substances the body needs to form a clot.
Where is Factor 9 in the blood?
Coagulation factor IX is made in the liver. This protein circulates in the bloodstream in an inactive form until an injury that damages blood vessels occurs. In response to injury, coagulation factor IX is activated by another coagulation factor called factor XIa.
What is a normal factor 9 level?
Normal plasma levels of factor IX are 50 to 150 units/dl. Patients with levels less than 1 unit/dl have severe disease, those with levels of 1 to 5 units/dl moderate disease, and those with levels greater than 5 units/dl mild disease. The half-life of factor IX is approximately 18 to 24 hours.