What is hydroxypropyl cyclodextrin?

What is hydroxypropyl cyclodextrin?

Product Description. 2-Hydroxypropyl-β-cyclodextrin (HP-β-CD) is a cyclic oligosaccharide containing seven D-(+)-glucopyranose units that is widely used to improve the aqueous solubility of various compounds, especially those containing a phenyl group.

What is hydroxypropyl cyclodextrin derived from?

What is Hydroxypropyl cyclodextrin? Hydroxypropyl cyclodextrin is a cyclic polysaccharide. It is a derivative of cyclodextrin, which can be formed from starch. It comes as a solid material.

Is 2-hydroxypropyl-β-cyclodextrin Hbcd toxic?

HP-beta-CD has been shown to be well tolerated in humans, with the main adverse event being diarrhoea and there have been no adverse events on kidney function, documented to date.

Is hydroxypropyl cyclodextrin safe for skin?

A plant- derived or synthetic carbohydrate that functions as a chelating agent and stabilizer. It is considered safe for use in cosmetics and has also been deemed safe for oral consumption (where its application, of course, differs from that of cosmetics).

What is 2-hydroxypropyl-β-cyclodextrin used for?

2-Hydroxypropyl-β-cyclodextrin (HP-β-CD) is a chemically modified derivative of β-cyclodextrin that exhibits an enhanced safety profile compared with its naturally occurring parent compound (4). HP-β-CD is used as an excipient for cardiac dysrhythmia, inflammation, and fungal disease medications (6).

What is 2 hydroxypropyl B cyclodextrin used for?

2-Hydroxypropyl-β-cyclodextrin (HP-β-CyD) is a cyclic oligosaccharide that is widely used as an enabling excipient in pharmaceutical formulations, but also as a cholesterol modifier.

Is hydroxypropyl good for skin?

The Cosmetics Ingredients Review, after performing studies on rats, have shown that HPMC is nontoxic and describes it as being “safe as cosmetic ingredients in the present practices of use and concentration.” The FDA have labelled HPMC as safe for general use, but limited in food, in which it is usually used as an …

Is beta cyclodextrin safe?

Most of the hydrophilic derivatives of natural cyclodextrins like 2-hydroxypropyl-β-cyclodextrin and sulphobutylether-β-cyclodextrin are considered safe for parenteral administration. Higher dose of cyclodextrins may be harmful.

Can cyclodextrin clear arteries?

Furthermore, when researchers used cyclodextrin to treat biopsies of plaques from human carotid arteries, they found similar results. The study points to cholesterol crystals as a target for treatment of atherosclerosis, meaning that using cyclodextrin to dissolve the crystals could affect how the disease is treated.

Is hydroxypropyl methylcellulose toxic?

It is now an EU and FDA-approved food additive and is considered non-toxic to humans.