What is hyperlipoproteinemia III?

Hyperlipoproteinemia type III is a genetic disorder that causes the body to breakdown (metabolize) fats (lipids) incorrectly. This results in the buildup of lipids in the body (hyperlipidemia) and can lead to the development of multiple small, yellow skin growths (xanthomas).

Is hyperlipoproteinemia hereditary?

Primary hyperlipoproteinemia is often genetic. It’s a result of a defect or mutation in lipoproteins. These changes result in problems with accumulation of lipids in your body. Secondary hyperlipoproteinemia is the result of other health conditions that lead to high levels of lipids in your body.

What lipoprotein abnormality occurs in type III hyperlipoproteinemia?

Type III HLP is caused by increases in IDL and remnant lipoproteins and is manifested by approximately equal increases in total cholesterol and TGs. Palmar xanthomas (xanthoma striata palmaris) may occur in type III HLP and are not observed in other disorders.

What is hyperlipoproteinemia mixed?

Mixed hyperlipidemia is a genetic disorder passed down through family members. If you have this disease, it means you have higher-than-normal levels of cholesterol, triglycerides, and other lipids in your blood. The disorder contributes to heart disease and early heart attacks.

What causes Type 2 Hyperlipoproteinemia?

Type IIb hyperlipoproteinemia is caused by mutation in the receptor-binding domain of APOLIPOPROTEIN B-100 which is a major component of LOW-DENSITY LIPOPROTEINS and VERY-LOW-DENSITY LIPOPROTEINS resulting in reduced clearance of these lipoproteins.

What is the best treatment for hypercholesterolemia?

Statins. Statins are usually the first hypercholesterolemia treatment used. Statins help reduce LDL levels by blocking a specific enzyme that’s necessary to produce cholesterol. Along with lowering LDL cholesterol, statins help prevent hardening of the arteries, which reduces the chances of a heart attack or stroke.

How is hyperlipoproteinemia type III most often inherited?

Hyperlipoproteinemia type III is most often inherited in an autosomal recessive pattern. Most genetic diseases are determined by the status of the two copies of a gene, one received from the father and one from the mother.

What kind of disease is dysbetalipoproteinemia type III?

Hyperlipoproteinemia type III, also known as dysbetalipoproteinemia or broad beta disease, is a rare genetic disorder characterized by improper breakdown (metabolism) of certain fatty materials known as lipids, specifically cholesterol and triglycerides. This results in the abnormal accumulation of lipids in the body (hyperlipidemia).

Is there a diagnostic test for hyperlipoproteinemia type 3?

There is no specific diagnostic test for hyperlipoproteinemia type III. A diagnosis is made based upon a thorough clinical evaluation, a detailed patient history, and identification of characteristic findings such as xanthoma striata palmaris.

What are the different types of hyperlipidemia Type 3?

Hyperlipoproteinemia type 3; Hyperlipoproteinemia type III; Broad-betalipoproteinemia; Hyperlipoproteinemia type 3; Hyperlipoproteinemia type III; Broad-betalipoproteinemia; Broad beta disease; Familial dysbetalipoproteinemia; Dysbetalipoproteinemia; Remnant removal disease See More. Categories: