What is rocuronium bromide used for?

Rocuronium bromide injection is indicated for inpatients and outpatients as an adjunct to general anesthesia to facilitate both rapid sequence and routine tracheal intubation, and to provide skeletal muscle relaxation during surgery or mechanical ventilation.

What drug classification is rocuronium?

Zemuron belongs to a class of drugs called Neuromuscular Blockers, Nondepolarizing.

Why is rocuronium used for surgery?

It works by blocking the signals between your nerves and your muscles. Rocuronium is given before general anesthesia in preparing you for surgery. Rocuronium helps to keep your body still during surgery. It also relaxes your throat so a breathing tube can be more easily inserted before the surgery.

Is rocuronium a paralytic?

Rocuronium, a nondepolarizing paralytic agent, has pharmacokinetic characteristics that provide optimal intubation conditions in almost the same time as succinylcholine, as long as the dose administered is at least 1 mg/kg. For this reason, it has been proposed as an alternative paralytic agent when RSI is indicated.

What is another name for rocuronium?

Introduced in 1994, rocuronium has rapid onset, and intermediate duration of action. It is commonly marketed under the trade names Zemuron and Esmeron.

What is the most common side effect of rocuronium?

In clinical trials, the most common adverse reactions (2%) are transient hypotension and hypertension.

Can rocuronium stop your heart?

Allergic reactions: Although there have been reports of cardiovascular side effects with the use of non-depolarizing neuromuscular agents like mivacurium and atracurium, rocuronium has been shown to be very cardiac stable and has no effects on heart rate or blood pressure.

What drug is given before intubation?

[4] Common sedative agents used during rapid sequence intubation include etomidate, ketamine, and propofol. Commonly used neuromuscular blocking agents are succinylcholine and rocuronium.

When is rocuronium used?

Rocuronium injection is used with general anesthesia medicines for rapid sequence intubation and routine tracheal intubation. This medicine is also used to help relax the muscles during surgery or mechanical ventilation. This medicine is to be given only by your doctor or other trained health professional.

What is the antidote for rocuronium?

Sugammadex, sold under the brand name Bridion, is a medication for the reversal of neuromuscular blockade induced by rocuronium and vecuronium in general anaesthesia. It is the first selective relaxant binding agent (SRBA).

Does rocuronium affect heart rate?

Results and Discussions: Rocuronium bolus affected the heart rate statistically significant in the first 5 minutes after the administration (initially 78 ± 20 bpm, after rocuronium bolus 111 ± 25 bpm with p ≤ 0.03).

Is there a contraindication for rocuronium bromide?

Rocuronium is contraindicated in patients known to have a rocuronium bromide hypersensitivity or other neuromuscular blocking agent hypersensitivity. Cross-reactivity between neuromuscular blocking agents, both depolarizing and non-depolarizing, has been reported.

How does rocuronium bromide work on cholinergic receptors?

Rocuronium bromide is a nondepolarizing neuromuscular blocking agent with a rapid to intermediate onset depending on dose and intermediate duration. It acts by competing for cholinergic receptors at the motor end-plate. This action is antagonized by acetylcholinesterase inhibitors, such as neostigmine and edrophonium.

When was rocuronium bromide introduced to the market?

Introduced in 1994, rocuronium has rapid onset, and intermediate duration of action. It is commonly marketed under the trade names Zemuron and Esmeron. The drug is associated with the risk of developing allergic reactions in some high-risk patients, such as those with asthma.

When to take rocuronium bromide for general anesthesia?

Rocuronium bromide injection is indicated for inpatients and outpatients as an adjunct to general anesthesia to facilitate both rapid sequence and routine tracheal intubation, and to provide skeletal muscle relaxation during surgery or mechanical ventilation. 2 DOSAGE AND ADMINISTRATION Rocuronium bromide is for intravenous use only.