What is sensipar medication used for?
Cinacalcet is used to treat increased amounts of a certain hormone (parathyroid) in people with long-term kidney disease who are on dialysis. It is also used to treat increased amounts of calcium in people with an overactive parathyroid gland or in people with cancer of the parathyroid gland.
What is calcimimetic medicine?
A calcimimetic is a pharmaceutical drug that mimics the action of calcium on tissues, by allosteric activation of the calcium-sensing receptor that is expressed in various human organ tissues. Calcimimetics are used to treat secondary hyperparathyroidism (SHPT).
Does sensipar cause weight gain?
Sensipar side effects muscle pain, tightness, or contraction; a seizure (convulsions); shortness of breath (even with mild exertion), swelling, rapid weight gain; signs of stomach bleeding – bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds; or.
Why is sensipar given to dialysis patients?
Cinacalcet is indicated for the treatment of hypercalcemia in patients with parathyroid carcinoma or for secondary hyperparathyroidism in patients with chronic kidney disease who require dialysis (11).
How quickly does Sensipar work?
In phase I-II studies, the maximum effect of cinacalcet was achieved within 2–6 hours after administration, with a terminal half-life of 30–40 hours (30, 31).
Does Sensipar lower blood pressure?
Low blood pressure: Blood pressure may occasionally drop when taking cinacalcet. Be alert for any lightheadedness, dizziness, or a faster-than-normal heart rate.
Is Cinacalcet a calcimimetic?
Cinacalcet, a calcimimetic that modulates the calcium-sensing receptor, reduces parathyroid hormone (PTH) secretion and lowers serum calcium and phosphorus concentrations in patients with end-stage renal disease (ESRD) and secondary HPT.
Is sensipar a calcimimetic?
Sensipar (cinacalcet) is a calcimimetic agent that decreases levels of parathyroid hormone (PTH), calcium, and phosphorous in the body used to treat hyperparathyroidism (overactive parathyroid glands) in people who are on long-term dialysis for kidney disease.
How long does it take Sensipar to work?
When do you use Sensipar?
- Sensipar® is taken once a day in one of the 5 recommended daily doses. Sensipar® tablets should be taken whole.
- Take Sensipar® with food or shortly after a meal. Consider taking Sensipar® at the same time, with the same meal, every day.
- Take Sensipar® at least 12 hours before your PTH blood test.
Does Sensipar Dialyze out?
No effect of renal function or dialysis on pharmacokinetics of cinacalcet (Sensipar/Mimpara)
Is Sensipar safe to take?
Sensipar (Cinacalcet) can be used for secondary (renal failure) hyperparathyroidism. If you are not getting kidney dialysis, then you probably should not take Sensipar. The most recent studies on Sensipar and calcium levels and parathyroid hormone are discussed. Sensipar is a drug that can be problematic (dangerous?)
What does Sensipar do to the calcium receptors?
Sensipar (cinacalcet) is a calcimimetic agent that increases the sensitivity of the calcium-sensing receptor to activation by extracellular calcium.
What do you need to know about Sensipar?
Medically reviewed by Sophia Entringer, PharmD Last updated on Apr 21, 2019. Sensipar (cinacalcet) decreases levels of parathyroid hormone (PTH), calcium, and phosphorous in the body. Sensipar is used to treat hyperparathyroidism (overactive functioning of the parathyroid glands) in people who are on long-term dialysis for kidney disease.
What is the molecular formula of Sensipar tablets?
Sensipar®(cinacalcet) is a calcimimetic agent that increases the sensitivity of the calcium-sensing receptor to activation by extracellular calcium. Its empirical formula is C22H22F3N⋅HCl with a molecular weight of 393.9 g/mol (hydrochloride salt) and 357.4 g/mol (free base). It has one chiral center having an R-absolute configuration.
When to take Sensipar for hypercalcemia in adults?
Sensipar is indicated for the treatment of hypercalcemia in adult patients with primary HPT for whom parathyroidectomywould be indicated on the basis of serum calcium levels, but who are unable to undergo parathyroidectomy [see Clinical Studies].