What is the AhR pathway?

The AhR genomic pathway. When a ligand crosses the plasma membrane (passive diffusion), it binds to the AhR (the PAS B domain). This allows the translocation of the ligand-receptor complex into the nucleus and the dissociation of the receptor complex.

Where are aryl hydrocarbon receptors?

The AhR protein contains several domains critical for function and is classified as a member of the basic helix-loop-helix/Per-Arnt-Sim (bHLH/PAS) family of transcription factors. The bHLH motif is located in the N-terminal of the protein and is a common entity in a variety of transcription factors.

Where in the cell would you expect to find an agonist occupied AhR receptor?

In the absence of bound agonist, the AHR is most commonly found in the cytoplasm in a complex with its chaperones heat shock protein 90 (Hsp90), P23 and aryl hydrocarbon receptor associated 9 (ARA9; aka AIP, XAP2).

What is an AhR ligand?

The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcriptional factor able to sense a wide range of structurally different exogenous and endogenous molecules. AhR ligands vary in their structure, and their binding affinity can significantly differ between mouse and human AhR [1].

What is an AHR agonist?

The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor with important functions in the immune response and cancer. AHR agonists are provided by the environment, the commensal flora and the metabolism.

What does AHR mean?

AHR

What is AHR in medical terms?

Science and medicine aHR, adjusted hazard ratio. AHr, ampere hour. Airway hyper-responsiveness.

What do dioxins do to the environment?

They can cause problems with reproduction, development, and the immune system. They can also disrupt hormones and lead to cancer. Dioxins, which are known as persistent environmental pollutants (POPs), can remain in the environment for many years. They are everywhere around us.

What is the meaning of AHR?

Acronym. Definition. AHR. American Historical Review (Journal of the American History Association) AHR.

What is Ahr?

American Hope Resources (AHR) is an organization that aims to empower Hardship Victims and their growing families to connect with other Hardship Victims in a completely refreshing & unique way socially.

What is AHR antagonist?

AHR (Aryl-hydrocarbon receptor; also bHLHE76) is a 110 kDa member of the bHLH/PAS transcription factor family. It is widely expressed (breast, lung, liver), and serves many functions. First, it binds multiple xenobiotic chemicals in the cytoplasm.

What does Ahr mean in statistics?

The crude and adjusted hazard ratios (cHR, aHR) with 95% confidence intervals (CIs) of total cholesterol in death by cardiovascular diseases in the study participants (n = 12,740)

How is the aryl hydrocarbon receptor ( AhR ) regulated?

AHR itself is regulated by the aryl hydrocarbon receptor repressor (AHRR, aka BHLHE77, KIAA1234), an evolutionarily conserved bHLH-PAS protein that inhibits both xenobiotic-induced and constitutively active AHR transcriptional activity in many species.

What kind of compounds can activate Ahr signaling?

Two major types of environmental compounds can activate AHR signaling: halogenated aromatic hydrocarbons such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and polycyclic aromatic hydrocarbons (PAH) such as benzo (a)pyrene.

Which is part of the AhR pathway does Ahr target?

AHR targets genes of Phase I and Phase II metabolism, such as cytochrome P450 1A1 (CYP1A1), cytochorme P450 1B1 (CYP1B1), NAD (P)H:quinone oxidoreductase I (NQO1) and aldehyde dehydrogenase 3 (ALHD3A1).

Where does AHRR compete with the ARNT complex?

AHRR resides predominantly in the nuclear compartment where it competes with AHR for binding to ARNT. As a result, there is competition between AHR:ARNT and AHRR:ARNT complexes for binding to XREs in target genes and AHRR can repress the transcription activity of AHR (Hahn et al. 2009, Haarmann-Stemmann & Abel 2006).