What is the meaning of efferocytosis?

What is the meaning of efferocytosis?

Efferocytosis is a term derived from the Greek (meaning to carry the dead to the grave), and refers to the phagocytic engulfment of a cellular corpse4, 6, 7. Both professional phagocytes (e.g. macrophages) and non-professional (e.g. neighboring) cells participate in efferocytosis.

What process is efferocytosis?

What is efferocytosis? Literally, efferocytosis is derived from the Latin word ‘efferre’ which translates ‘to take to the grave’. In cell biological terms, efferocytosis describes the process by which dead or dying cells are engulfed and digested by phagocytes (Figure 1A).

What is the difference between efferocytosis and phagocytosis?

It is thought that the molecular mechanisms of efferocytosis resembles those of phagocytosis, with the important distinction that the ultimate outcome of phagocytosis is the induction of inflammation and antigen presentation, whereas efferocytosis is immunologically silent.

What triggers efferocytosis?

Stabilin receptors (Stab1, Stab2) are type I surface receptors that trigger efferocytosis through direct interaction with PtdSer (90–92).

What does apoptosis mean in biology?

cell death
Listen to pronunciation. (A-pop-TOH-sis) A type of cell death in which a series of molecular steps in a cell lead to its death. This is one method the body uses to get rid of unneeded or abnormal cells.

What causes Necroptosis?

Necroptosis is a programmed form of necrosis, or inflammatory cell death. Conventionally, necrosis is associated with unprogrammed cell death resulting from cellular damage or infiltration by pathogens, in contrast to orderly, programmed cell death via apoptosis.

What do macrophages turn into?

Macrophages originate from blood monocytes that leave the circulation to differentiate in different tissues….Macrophages.

Type of macrophage Location Function
Kupffer cells Liver Initiate immune responses and hepatic tissue remodelling.

What is a necrotic cell?

Necrosis (from Ancient Greek νέκρωσις, nékrōsis, “death”) is a form of cell injury which results in the premature death of cells in living tissue by autolysis. Necrosis is caused by factors external to the cell or tissue, such as infection, or trauma which result in the unregulated digestion of cell components.

How do you increase efferocytosis?

The process of resolution in atherosclerosis can also enhance efferocytosis. A recent study showed that administration of RvD1 to Western diet-fed Ldlr−/− mice significantly increased the SPM:leukotriene ratio, while also decreasing plaque necrosis and enhancing lesional efferocytosis (99).

What is the best definition of apoptosis?

Listen to pronunciation. (A-pop-TOH-sis) A type of cell death in which a series of molecular steps in a cell lead to its death. This is one method the body uses to get rid of unneeded or abnormal cells.

Why is necroptosis important?

The resulting necroptosis is vital to provoke innate immune response by killing virus-infected cells and releasing danger signals from host cells into external milieu. Furthermore, necroptosis in T cells regulates antigen-activated T-cell proliferation and survival.

What are some examples for exocytosis?

A good example of exocytosis in the transportation of glucagon from the pancreas in the Islets of Langerhans into the liver where they are broken down into glycogen which is

  • the glucagon and insulin are stored in the secretory vesicles of the pancreas.
  • The pancreas also releases some digestive enzymes by exocytosis.
  • What does exocytosis mean?

    Definition of exocytosis : the release of cellular substances (such as secretory products) contained in cell vesicles by fusion of the vesicular membrane with the plasma membrane and subsequent release of the contents to the exterior of the cell

    What is exocytosis process?

    Exocytosis is the cellular process in which intracellular vesicles in the cytoplasm fuse with the plasma membrane and release or “secrete” their contents into the extracellular space. Exocytosis can be constitutive (occurring all the time) or regulated.