Users' questions

What medications are used for uterine atony?

What medications are used for uterine atony?

Initial Medical Treatment

  • Oxytocin (Pitocin) can be given IV 10 to 40 units per 1000 ml or 10 units intramuscularly (IM).
  • Methylergonovine (Methergine) given IM 0.2 mg.
  • 15-methyl-PGF2-alpha (Hemabate) given IM 0.25 mg.
  • Misoprostol (Cytotec): 800 to 1000 mg placed rectally.

What can you do for uterine atony?

Treatment for Atony of the Uterus

  1. uterine massage, which involves your doctor placing one hand in the vagina and pushing against the uterus while their other hand compresses the uterus through the abdominal wall.
  2. uterotonic drugs including oxytocin, methylergonovine (Methergine), and prostaglandins, such as Hemabate.

How does macrosomia cause uterine atony?

Bleeding after delivery. Fetal macrosomia increases the risk that your uterine muscles won’t properly contract after you give birth (uterine atony). This can lead to potentially serious bleeding after delivery.

Which medications are used to manage PPH?

The medications most commonly used in PPH management are uterotonic agents. These medications include oxytocin (Pitocin®), misoprostol (Cytotec®), methylergonovine maleate (Methergine®,), carboprost tromethamine (Hemabate®), and dinoprostone (Prostin E2®).

Can full bladder cause uterine atony?

Uterine atony can also occur when the uterine muscles fatigue during the delivery process because of a prolonged labor. It can also happen when a woman is unable to empty her bladder, since a full bladder can push against the uterus and interfere with uterine contractions.

What medications should not be given during PPH?

Oxytocin, methylergonovine, and carboprost are approved by the FDA for PPH management, while misoprostol and tranexamic acid are not.

What causes a PPH?

Four T’s Mnemonic for the Specific Causes of Postpartum Hemorrhage

Pathology Specific cause Approximate incidence (%)
Tone Atonic uterus 70
Trauma Lacerations, hematomas, inversion, rupture 20
Tissue Retained tissue, invasive placenta 10
Thrombin Coagulopathies 1

Why uterine atony is bad?

Therefore, a lack of uterine muscle contraction can lead to an acute hemorrhage, as the vasculature is not being sufficiently compressed. Uterine atony is the most common cause of postpartum hemorrhage, which is an emergency and potential cause of fatality….

Uterine atony
Frequency 80% of postpartum bleeding

What causes PPH?

Uterine atony. This is the most common cause of PPH. It happens when the muscles in your uterus don’t contract (tighten) well after birth. Uterine contractions after birth help stop bleeding from the place in the uterus where the placenta breaks away.

Who is at risk for uterine Atony?

Risk factors for uterine atony include uterine overdistention secondary to hydramnios, multiple gestation, use of oxytocin, fetal macrosomia, high parity, rapid or prolonged labor, intra-amniotic infection and use of uterine-relaxing agents.

Which is the best medication for uterine atony?

DOI: 10.1016/j.anclin.2017.01.007 Abstract Uterine atony is a common cause of primary postpartum hemorrhage, which remains a major cause of pregnancy-related mortality for women worldwide. Oxytocin, methylergonovine, carboprost, and misoprostol are commonly used to restore uterine tone.

What can be used instead of oxytocin for uterine contraction?

Ergotamines (eg, ergonovine, methylergonovine [Methergine]) can be used instead of, or with the failure of oxytocin, to facilitate uterine contraction. [ 20]

Which is the best second line uterotonic medicine?

Methylergonovine and carboprost are both highly effective second-line agents with severe potential side effects. Recent studies have called into question the effectiveness of misoprostol as an adjunct to other uterotonic agents, but it remains a useful therapeutic in resource-limited practice environments.

Who are the authors of uterotonic medication anclin?

2017 Jun;35(2):207-219.doi: 10.1016/j.anclin.2017.01.007. Epub 2017 Mar 30. Authors Cristianna Vallera 1 , Lynn O Choi 2 , Catherine M Cha 2 , Richard W Hong 2 Affiliations