How does B cell differentiation occur?

The antigen-dependent phase of B cell development occurs following B cell activation by antigen binding and co-stimulation. These signals promote B cell differentiation into either memory B cells or terminal, antibody-secreting plasma cells.

What are the stages of B cell development?

As they develop, B cells go through 6 stages: They start as common lymphoid progenitor cells, then become early pro-B cells, then late pro-B cells, then large pre-b cells, then small pre-B cells, and finally immature B cells.

What steps are required for most B cells to become fully activated and differentiate into plasma cells?

Memory B cells require an activation signal in addition to specific antigen binding in order to produce new plasma cells. What is the second, activating signal? Though each antibody is specific to one antigen, highly similar antigens may be recognized by the same antibody.

How long does it take for B cell to mature?

Such studies have largely resolved the issue, concluding that about 85% of peripheral B cells are phenotypically mature and display first-order exponential kinetics defined by a half-life of 5-6 weeks, whilst the remainder are short-lived with a life span of several days.

What stimulates the maturation of B cells?

The peptide:MHC class II complex can be recognized by antigen-specific armed helper T cells, stimulating them to make proteins that, in turn, cause the B cell to proliferate and its progeny to differentiate into antibody-secreting cells.

Which of the following is responsible for B-cell activation?

Which of the following is responsible for B-cell activation? Explanation: The activation of mature B-cell is done by antigen. When antigen come in contact with B-cells, it undergoes clonal proliferation and divided into memory cells and plasma cells.

Which of the following is responsible for B cell activation?

What are the two types of B cells?

There are four main types of B cells – transitional, naive, plasma, and memory – that all have their own purpose in the maturation process.

What is the first step in B cell activation?

The first step of B cell maturation is an assessment of the functionality of their antigen-binding receptors. This occurs through positive selection for B cells with normal functional receptors. A mechanism of negative selection is then used to eliminate self-reacting B cells and minimize the risk of autoimmunity.

Where does B cell activation occur?

B cell activation occurs in the secondary lymphoid organs (SLOs), such as the spleen and lymph nodes. After B cells mature in the bone marrow, they migrate through the blood to SLOs, which receive a constant supply of antigen through circulating lymph.

How long do B cells live in culture?

This culture system is capable of supporting vigorous B-cell proliferation for at least 16 days. Indeed, CD B cells are capable of continued proliferation for at least another week in fresh cultures (data not shown). Vigorous proliferation of human mature, naïve B cells in vitro.