Can Herceptin be given subcutaneously?

On February 28, 2019, the Food and Drug Administration approved trastuzumab and hyaluronidase-oysk injection,for subcutaneous use (Herceptin Hylecta, Genentech Inc.).

How do you give Herceptin subcutaneous injection?

The recommended dose is 600 mg (in a solution of 5 mL). HERCEPTIN SC is given as a subcutaneous injection (under the skin) over 2 to 5 minutes every three weeks. The injection site should be alternated between the left and right thigh. New injections should be given at least 2.5 cm away from an old site.

How is Herceptin injection given?

Traditional Herceptin is given by intravenous (IV) infusion, which means the medicine is delivered directly into your bloodsteam through an IV or port. The first dose of Herceptin takes about 90 minutes. After that, it only takes about 30 minutes to get other doses of Herceptin.

What is Herceptin SC?

Herceptin SC is a subcutaneous formulation that contains hyaluronidase, which temporarily and reversibly degrades hyaluronan, a gel-like substance that forms a barrier between cells under the skin. This enables the subcutaneous formulation of Herceptin to be rapidly dispersed and absorbed over a greater area.

What are the side effects of Herceptin injections?

Side effects of herceptin

• a reaction to the medicine, such as chills, a high temperature, swelling of the face and lips, headache, hot flushes, feeling sick, wheezing and breathlessness.
• tiredness and difficulty sleeping (insomnia)
• diarrhoea or constipation.

What is the difference between Herceptin and Herceptin Hylecta?

Herceptin contains one active ingredient, trastuzumab, and is given as an intravenous (IV) infusion slowly into a vein. Herceptin Hylecta contains two active ingredients, trastuzumab and hyaluronidase-oysk, and is given as a subcutaneous injection, which is an injection that goes under the skin.

Do you lose your hair with Herceptin?

Answer: No, hair loss is not a common side effect of trastuzumab. If you are receiving trastuzumab in combination with chemotherapy, you may experience hair loss due to the chemotherapy.

Why is Herceptin given for a year?

Since 2005, the standard of care has been to give Herceptin for 1 year after surgery and chemotherapy to reduce the risk of recurrence (the cancer coming back) of early-stage, HER2-positive breast cancer. Like most cancer treatments, Herceptin can cause side effects, including possible heart damage.

Does Herceptin lower your immune system?

Does trastuzumab (Herceptin) affect the immune system? Having trastuzumab (Herceptin) could mean you’re more at risk of getting coronavirus or becoming very ill if you get it. The risk is likely to be higher if you’re having it with chemotherapy.

What can I expect from Herceptin treatment?

Common Herceptin Hylecta side effects include:

• fatigue.
• joint pain.
• diarrhea.
• injection site reaction.
• upper respiratory tract infection.
• rash.
• muscle pain.
• nausea.

Is Herceptin effective without chemo?

Disease-free survival is how long the women lived without the cancer coming back. Overall survival is how long the women lived, whether or not the cancer came back. Three-year disease-free survival rates were: 89.5% for women treated with Herceptin alone.

What is the success rate of Herceptin?

At 10 years after treatment, overall survival was better in women who were treated with Herceptin: 84% of the women who received chemotherapy plus Herceptin were alive. 75.2% of the women who received chemotherapy alone were alive.