What is the survival rate for double-hit lymphoma?

A 2014 multicenter retrospective study of 311 patients with double-hit lymphoma showed median progression-free survival to be 11 months and median overall survival to be 22 months. At 2 years, a “tail of the curve” showed about 40% of patients were free of disease progression, and close to 50% were still alive.

Does double-hit lymphoma come back?

There is no standard treatment for double-hit or triple-hit lymphoma. These types of lymphoma can be difficult to treat. They have a higher risk of coming back (relapsing) than more common types of high-grade B-cell lymphoma.

What is da Epoch R?

An abbreviation for a chemotherapy combination used to treat certain types of non-Hodgkin lymphoma. It includes the drugs etoposide phosphate, prednisone, vincristine sulfate (Oncovin), cyclophosphamide, doxorubicin hydrochloride (hydroxydaunorubicin), and rituximab.

Can you survive double expressor lymphoma?

Patients carrying the double expression of MYC and BCL2 (double expressor, DE) with or without concomitant translocations of MYC and BCL2, and/or BCL6 genes have a dismal prognosis. In patients affected by DE DLBCL without translocations, the 5-year overall survival (OS) is ~40% with R-CHOP.

Is double hit lymphoma rare?

Although double-hit lymphoma is rare, we’ve come a long way understanding it better.

What stage is double hit lymphoma?

Double-hit lymphoma (DHL) is a rare type of aggressive B-cell lymphoma defined as a high-grade B-cell lymphoma (HGBCL) with the presence of MYC, BCL2 and/or BCL6 rearrangements. Patients usually present with rapidly progressive and advanced stage of disease and, commonly, with extranodal involvement.

Can you cure double hit lymphoma?

Diffuse large B-cell lymphoma is the most common lymphoma diagnosed in the Western world and is curable in approximately two-thirds of cases with standard chemoimmunotherapy approaches.

How often is R-EPOCH given?

DA-EPOCH-R is typically repeated every 21 – 28 days. This is known as one Cycle. Each cycle may be repeated up to 8 times, depending upon the stage of the disease.

What are the side effects of R-EPOCH?

Swelling of the body. Nausea, vomiting, constipation, diarrhea, loss of appetite, pain in belly. Increased appetite and weight gain in the belly, face, back and shoulders. Sores in mouth.

Can you survive triple hit lymphoma?

Patients with triple hit lymphoma had a very poor prognosis, with an overall survival of 18 months, similar to the overall survival of patients with MYC/BCL6 double hit lymphoma (17 months) and those with MYC/BCL2 double hit lymphoma (20 months) (Fig.

How is double hit lymphoma treated?

Relapsed double-hit lymphoma and novel agents The standard curative approach to the treatment of relapsed aggressive lymphoma in patients who are fit is to administer non–cross-resistant salvage chemotherapy followed by consolidation with high-dose therapy and ASCT.

How effective is R-EPOCH?

The patients received DA-EPOCH-R administered with CNS prophylaxis for six cycles. Primary endpoints included event-free (EFS) and overall survival (OS). The overall response rate was 87 percent, and 74 percent achieved a complete response. The 48-month EFS and OS were 71 percent and 77 percent respectively.

When did I get diagnosed with double hit lymphoma?

I’m a 42 yo diagnosed with a high grade “double hit” lymphoma in July 2012: it is considered one of the most aggressive sub classes of DLBCL with an add’l mutation characteristic of BL. I’ve completed six cycles of DA R-EPOCH.

How many cycles of DA R-EPOCH for lymphoma?

The 2nd onc from MSKCC recommended 6 cycles of DA R-EPOCH + CNS Prophylaxis + “mop up” with SCT. The other two lymphoma specialists recommend a more aggressive regimen, essentially higher dosages of MEGA chemo, but they don’t think CNS Prophylaxis or SCT is necessary since my BMB was negative for lymphoma & the cancer had not metastasized.

Which is better epoch or rituximab for double hit DLBCL?

References (1) Dodero A. and Guidetti A.et al.Dose-adjusted EPOCH plus rituximab improves the clinical outcome of young patients affected by double expressor diffuse large B-cell lymphoma. Leukemia. 2019 Jan 10. DOI: 10.1038/s41375-018-0320-9[Epub ahead of print].

What are the genes for diffuse large B-cell lymphoma?

Some background. Diffuse large B-cell lymphoma (DLBCL) is a common type of non-Hodgkin lymphoma. There are three genes which are commonly mutated in DLBCL. These genes are MYC, BCL2 and BCL6. Double-hit lymphoma (DHL) is a type of DLBCL where MYC and either BCL2 or BCL6 are mutated. DHL is more aggressive than traditional DLBCL. Patients…